Calmer Canine uses tPEMF (targeted pulsed electromagnetic field) therapy to improve canine separation anxiety.
tPEMF produced by the Calmer Canine device delivers a signal, which is targeted to the brains' nerve cells. This causes the cells to produce more Nitric Oxide, an important molecule that stimulates cellular repair, as well as triggering anti-inflammatory responses.
Nitric Oxide prevents the production of pro-inflammatory cytokines or messengers, which are cell signaling molecules that trigger inflammation and make a disease worse. It also increases the number of anti-inflammatory cytokines or are cell signaling molecules that reduce inflammation and promote healing. Additionally, Nitric Oxide promotes the creation of endorphins, serotonin, and dopamine- "feel good" hormones that produces positive feelings of happiness and relaxation.
As a result, there is a reduction in inflammation of the amygdala- the part of the brain that is in charge of fear and emotional responses, where an overactive and anxious brain is rebalanced and causes less anxiety in dogs.
The results of a clinical trial were published in December 2021 in Frontiers in Veterinary Science, please click the button below to read the study.